FOLINIC ACID PROTECTION AGAINST NITROUS OXIDE TERATOGENICITY IN THE RAT
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چکیده
منابع مشابه
Folinic acid protection against nitrous oxide teratogenicity in the rat.
The Sprague-Dawley rat was used to demonstrate the effect of nitrous oxide, with and without folinic pretreatment, on reproductive indices and fetal development. One of the objectives of the investigation was to test the hypothesis that at least some of the teratogenic effect of nitrous oxide is related to interference with folate metabolism. Groups of animals were exposed to 70-75% nitrous oxi...
متن کاملPrevention of nitrous oxide-induced megaloblastic changes in bone marrow using folinic acid.
Prolonged anaesthesia with nitrous oxide inactivates vitamin B12 and impairs DNA synthesis in bone marrow cells. The use of parenteral folinic acid in the prevention of these toxic effects has been studied in 11 patients, ventilated artificially with nitrous oxide in oxygen for 24 h. Bone marrow aspirates were performed before and after exposure to nitrous oxide. They were assessed morphologica...
متن کاملMegaloblastic bone marrow changes after repeated nitrous oxide anaesthesia. Reversal with folinic acid.
A seriously ill patient was found to have megaloblastic changes in his bone marrow after a nitrous oxide anaesthesia which lasted for 105 min. After an interval of 7 h a second nitrous oxide anaesthetic was administered, during which the patient received 30 mg of folinic acid. His marrow was normal when assessed 4 h later.
متن کاملnitrous oxide on rat fertility and pregnancy
High incidences of cancer, hepatic disease, renal disease, spontaneous abortion, premature delivery, and congenital deformities in their offspring have been reported amongst operation-room personnel. These conditions have been attributed to their exposure to anesthetic gases. Dentists who are exposed to anesthetic gases are also reported to have high incidences of these diseases. While nitrous ...
متن کاملP110: Nitrous Oxide and Neuroinflammation
Nitrous oxide was an anaesthetic gas that was used for many years. There were many anaesthetic drugs in operations with many side effects. Nitrous oxide had some side effects too. But it was a safe gas in many times. In hospital personnel who worked in operating rooms exposure to this gas was important. The objective of this study was the introduction of nitrous oxide and neurologic side ...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1986
ISSN: 0007-0912
DOI: 10.1093/bja/58.5.528